| month | day | visitor | score | home | score |
|---|
| November | 5, 2024 | Pelicans | 106 | Spurs | 109 |
| November | 8, 2024 | Spurs | 107 | Rockets | 110 |
| November | 9, 2024 | Mavericks | 79 | Spurs | 97 |
| November | 11, 2024 | Nets | 104 | Spurs | 120 |
| November | 14, 2024 | Blazers | 87 | Spurs | 104 |
| November | 15, 2024 | Jazz | 76 | Spurs | 106 |
| November | 17, 2024 | Spurs | 103 | Warriors | 111 |
| November | 18, 2024 | Hawks | 75 | Spurs | 126 |
| November | 19, 2024 | Grizzlies | 91 | Spurs | 102 |
| November | 20, 2024 | Pelicans | 97 | Spurs | 85 |
| November | 23, 2024 | Mavericks | 80 | Spurs | 116 |
| November | 24, 2024 | Spurs | 88 | Jazz | 89 |
| November | 26, 2024 | Spurs | 92 | Grizzlies | 110 |
| November | 29, 2024 | Spurs | 103 | Clippers | 104 |
| December | 2, 2024 | Spurs | 114 | Cavaliers | 112 |
| December | 4, 2024 | Nuggets | 113 | Spurs | 115 |
| December | 5, 2024 | Rockets | 94 | Spurs | 122 |
| December | 7, 2024 | Magic | 94 | Spurs | 141 |
| December | 10, 2024 | Spurs | 110 | Heat | 113 |
| December | 18, 2024 | Spurs | 129 | Wizards | 106 |
| December | 19, 2024 | Nuggets | 115 | Spurs | 122 |
| December | 22, 2024 | Spurs | 129 | Kings | 122 |
| December | 23, 2024 | Pelicans | 108 | Spurs | 131 |
| December | 26, 2024 | Spurs | 164 | Blazers | 125 |
| December | 28, 2024 | Spurs | 101 | Jazz | 71 |
| January | 4, 2025 | Spurs | 131 | Blazers | 117 |
| January | 6, 2025 | Spurs | 118 | Knicks | 117 |
| January | 7, 2025 | Bucks | 138 | Spurs | 128 |
| January | 10, 2025 | Spurs | 146 | Wolves | 136 |
| January | 11, 2025 | Nuggets | 106 | Spurs | 144 |
| January | 12, 2025 | Wolves | 136 | Spurs | 145 |
| January | 13, 2025 | Spurs | 113 | Mavericks | 83 |
| January | 14, 2025 | Grizzlies | 120 | Spurs | 90 |
| January | 15, 2025 | Spurs | 124 | Wolves | 118 |
| January | 16, 2025 | Spurs | 115 | 76ers | 121 |
| January | 18, 2025 | Spurs | 148 | Bucks | 128 |
| January | 20, 2025 | Raptors | 102 | Spurs | 119 |
| January | 22, 2025 | Rockets | 112 | Spurs | 126 |
| January | 24, 2025 | Spurs | 137 | Celtics | 101 |
| January | 25, 2025 | Wizards | | Spurs | |
| January | 29, 2025 | Pacers | | Spurs | |
| January | 31, 2025 | Bulls | | Spurs | |
| February | 2, 2025 | Cavaliers | | Spurs | |
| February | 4, 2025 | Spurs | | Mavericks | |
| February | 7, 2025 | Grizzlies | | Spurs | |
| February | 8, 2025 | Spurs | | Kings | |
| February | 9, 2025 | Clippers | | Spurs | |
| February | 17, 2025 | Spurs | | Pistons | |
| February | 18, 2025 | Thunder | | Spurs | |
| February | 20, 2025 | 76ers | | Spurs | |
| February | 23, 2025 | Rockets | | Spurs | |
| February | 24, 2025 | Spurs | | Thunder | |
| February | 25, 2025 | Wolves | | Spurs | |
| February | 26, 2025 | Spurs | | Pelicans | |
| February | 27, 2025 | Pistons | | Spurs | |
| February | 28, 2025 | Spurs | | Nuggets | |
| March | 1, 2025 | Spurs | | Lakers | |
| March | 2, 2025 | Mavericks | | Spurs | |
| March | 4, 2025 | Spurs | | Magic | |
| March | 5, 2025 | Spurs | | Bulls | |
| March | 9, 2025 | Spurs | | Nets | |
| March | 10, 2025 | Suns | | Spurs | |
| March | 11, 2025 | Spurs | | Pacers | |
| March | 12, 2025 | Celtics | | Spurs | |
| March | 14, 2025 | Spurs | | Hawks | |
| March | 17, 2025 | Spurs | | Lakers | |
| March | 22, 2025 | Kings | | Spurs | |
| March | 23, 2025 | Spurs | | Wolves | |
| March | 29, 2025 | Spurs | | Raptors | |
| March | 31, 2025 | Heat | | Spurs | |
| April | 2, 2025 | Spurs | | Hornets | |
| April | 5, 2025 | Spurs | | Thunder | |
| April | 8, 2025 | Spurs | | Suns | |
| April | 14, 2025 | Spurs | | Clippers | |
| April | 15, 2025 | Knicks | | Spurs | |
| April | 16, 2025 | Lakers | | Spurs | |
| April | 23, 2025 | Jazz | | Spurs | |
| April | 24, 2025 | Spurs | | Grizzlies | |
| April | 26, 2025 | Warriors | | Spurs | |
| April | 27, 2025 | Spurs | | Pelicans | |
| April | 28, 2025 | Spurs | | Nuggets | |
| April | 30, 2025 | Spurs | | Rockets | |
| May | 3, 2025 | Hornets | | Spurs | |
| May | 5, 2025 | Jazz | | Spurs | |